|The long-term mission of our research program is to obtain an integrated,
quantitative understanding of cells and viruses at molecular resolution. We take an interdisciplinary approach to this
problem by combining novel technologies for 3D imaging with computational and cell biological tools.
Our research efforts are presently focused on three areas:
(i) determination of the dynamic architecture of the bacterial chemotaxis
apparatus and quantitative understanding of steps in signal transduction, (ii) determination of the structure, and mechanisms underlying
neutralization and cellular entry of HIV, and (iii) the development of novel technologies for 3D imaging of cells and tissues, with
particular emphasis on methods for understanding and diagnosing structural signatures of cancer cells.