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Structural States of a Brain Receptor Revealed
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The long-term mission of our research program is to obtain an integrated, quantitative understanding of cells and viruses at molecular resolution. We take an interdisciplinary approach to this problem by combining novel technologies for 3D imaging with computational and cell biological tools.

Our research efforts are presently focused on four areas:

  1. Structural analysis of membrane transporters and dynamic protein complexes involved in signaling and metabolism

  2. Structure and structural variations of enveloped virus glycoproteins and their applicability to vaccine design

  3. 3D subcellular imaging with correlative light and electron microscopy to explore host-pathogen interactions

  4. The development of methods for high-resolution cryo-EM
3D reconstruction of a melanoma cell

The technical infrastructure of the laboratory includes a variety of high-end electron microscopes for TEM and FIB-SEM imaging, as well as infrastructure for biochemistry, cell biology, and biophysical analysis.

If you are interested in applying for a position as a student or postdoctoral fellow, please send a CV, a brief statement of research interests, and the names of three references by electronic or regular mail to:

Sriram Subramaniam
Biophysics Section
Laboratory of Cell Biology
National Cancer Institute
Bethesda, MD 20892
FAX: (301) 480-3834
TEL: (301) 594-2062
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