Foundations for Understanding Essentials of Cell Division

December 21, 2017

In a recent news post, CCR highlights the Subramaniam lab's recent publication in the journal Science. This research unravels new aspects of kinetochore assembly and chromosome organization, and results from an intra-CCR collaboration with the Bai and Kelly labs.

Cryo-electron microscopy makes waves in pharma labs

November 28, 2017

In a news and analysis article, Nature Reviews Drug Discovery discusses recent changes in the cryo-EM field, and how pharma labs are beginning to use the technology for drug discovery. The article highlights the Subramaniam lab's 2016 publication of the structures of glutamate dehydrogenase and isocitrate dehydrogenase.

CRISPR Seen in Action

October 10, 2017

In their Research Highlights section, Nature magazine features the recent paper from the Subramaniam lab, published in the journal Cell, on the structural changes of Pseudomonas aeruginosa CRISPR complexes upon DNA binding. The paper describes details of the molecular mechanisms of phage-derived CRISPR inhbitiors.

Watching the Action Unfold

October 5, 2017

In a news post, CCR highlights the Subramaniam lab's recent publication in the journal Cell, where cryo-EM analysis revealed novel structural changes upon DNA binding to the CRISPR complex Csy, and molecular mechanisms for the action of CRISPR inhibitors.

Crazy for cryo-EM

May 1, 2017

In a feature article, ASBMB Today discusses the creation of several new cryo-EM facilities, including NCI's new National Cryo-Electron Microscopy Facility, which will support cryo-EM research across the country. The article includes comments by a number of prominent cryo-EM scientists, including Sriram Subramaniam.

Researchers discover mitochondrial “circuit breaker” that protects heart from damage

April 17, 2017

In a press release, the National Heart, Lung, and Blood Institute (NHLBI) highlights a recent publication by Glancy, et al. in the journal Cell Reports from the Subramaniam and Balaban labs. This study revealed how the structure of mitochondria in heart muscle cells can protect the heart when sections of the mitochondrial network are damaged.

HILLEMAN Documentary Comes to Germantown, MD

February 24, 2017

Sriram Subramaniam joins filmmaker Donald Mitchell for a screening of HILLEMAN: A Perilous Quest to Save the World's Children, a documentary about Dr. Maurice Hilleman and his pioneering work in the vaccine field. Some animations in the film were inspired by research at the Subramaniam Laboratory.

The big reveal: Beta-galactosidase and cryo-EM

December 23, 2016

Ewan Birney, the Director of EMBL-EBI, features β-galactosidase as a "Structure of Christmas" on his blog. He discusses the history of cryo-EM, and the impact of the Subramaniam lab's 2.2 Å resolution structure of β-galactosidase, published in 2015.

Record-breaking protein images have applications for drug discovery

August, 2016

Physics Today, a publication focusing on the latest in the physical sciences, discusses recent developments in the cryo-EM field, highlighting the Subramaniam lab's recent publication of high resolution structures of GDH, LDH, and IDH in the journal Cell.

Frederick lab using new high-tech microscopes in cancer research

July 19, 2016

The Frederick News-Post discusses the work of the Center for Molecular Microscopy and the Ras Initiative at the Advanced Technology Research Facility in Frederick, highlighting the use of the latest generation of electron and light microscopes to visualize cells and proteins in 3D.